Danny is credited as being part of  the British house scene since its beginnings. Born in Streatham, London, he DJ'd as a teenager, and  was a regularly seen  playing  hip hop, funk and soul in pubs around South London. During a vacation to the Spanish island of Ibiza in 1987, he became aware of a mix of soul, Italian disco and house which was called 'Balearic'.

Danny Rampling along with Nicky Holloway and Paul Oakenfold returned to Britain and popularized the Ibiza beat through clubs, Kiss FM, and warehouse parties (later to be known as raves).  Danny's  'Shoom' night near Southwark Bridge was one of  the most important club nights for early house music. In 1989, Danny began playing in Europe and in 1990 founded the Pure club night. His sound changed from acid house to harder trance during the 1990s. In 1993 he had a chart hit with a single I am the music, hear me .

He joined the BBC's Radio 1 in November 1994 presenting The Lovegroove Dance Party (Saturday evenings 7PM). He has released several  mix CD's including Club Nation. Danny has said "I just go out there and play good music and that's it. That's my job, to go out and give people a good time".

As well as presenting for Radio 1, Danny is resident DJ at London's Turnmills club.

He left Radio 1 in Dec 2005 to pursue his dream of being a restaurateur.